A cached bundle of annotations (CADD, dbNSFP, ClinVar snippets, dbSNP)
keyed by hg19 genomic HGVS. Use it as a "what else is already stored?"
pass, then confirm any score you will write at the live source — Ensembl
VEP with CADD=1 (ensembl.md §6), not this cache.
Docs: https://docs.myvariant.info/en/latest/ All figures verified 2026-09-10.
GET https://myvariant.info/v1/query?q={rsID or text}
GET https://myvariant.info/v1/variant/{hg19_id}
/variant/ ids look like chr17:g.7578406C>G. That is hg19. A GRCh38
g. string on this endpoint 404s.
GET /v1/query?q=rs28934578
HTTP 200. First hit:
| Field | Value |
|---|---|
_id |
chr17:g.7578406C>G |
cadd.phred |
35 |
hg19.start |
7578406 |
Live CADD via VEP (CADD=1) for GRCh38 17:7675088 C>G the same day was
29.4. If you report 35 as "the CADD score," you are reporting a cache.
GET /v1/variant/chr17:g.7674220G>A
GET /v1/variant/chr17:g.7674220G>A?assembly=hg38
GET /v1/variant/chr17:g.7577538G>A
All HTTP 404. assembly=hg38 does not make a GRCh38 g. id valid here.
Query by rsID, then use the returned _id if you need /variant/.
_id is hg19. Write that down.cadd.phred is not live CADD v1.7. Treat a gap of ≥ 0.5 PHRED
as "this is not the score to write."clinvar.md.