Human Protein Atlas (HPA)

Base URL

https://www.proteinatlas.org

Auth

No API key required.

Key Endpoints

Purpose	URL Pattern
Gene data by Ensembl ID	`/{ENSEMBL_ID}.json`
Gene data by symbol	`/{GENE_NAME}.json`
Search (JSON)	`/search/{QUERY}?format=json`
Search (XML)	`/search/{QUERY}?format=xml`

Example Calls

# Gene data by Ensembl ID
https://www.proteinatlas.org/ENSG00000141510.json

# Gene data by symbol
https://www.proteinatlas.org/TP53.json

# Search
https://www.proteinatlas.org/search/TP53?format=json

Response Format (JSON, gene endpoint)

{
  "Gene": "TP53",
  "Gene synonym": ["p53", "LFS1"],
  "Ensembl": "ENSG00000141510",
  "Gene description": "tumor protein p53",
  "Uniprot": ["P04637"],
  "Chromosome": "17",
  "Protein class": ["Transcription factors"],
  "RNA tissue specificity": "Low tissue specificity",
  "Subcellular location": ["Nucleoplasm"],
  "Pathology prognostics": [...]
}

Bulk Downloads

For large-scale work, use TSV files from https://www.proteinatlas.org/about/download: - normal_tissue.tsv — IHC tissue expression - rna_tissue_consensus.tsv — RNA consensus - subcellular_location.tsv - pathology.tsv — cancer prognostics

Rate Limits

No published limits. Be reasonable. Prefer bulk downloads for large queries.