{
  "schema_version": "1.0",
  "profile_id": "REPLACE_WITH_PROFILE_ID",
  "title": "Human-Judged GRADE Evidence Profile",
  "data_level": "published_aggregate_evidence",
  "human_judgments_required": true,
  "auto_grade": false,
  "intended_use": "Research evidence synthesis and panel documentation only.",
  "prohibited_uses": [
    "No automatic evidence grade or recommendation strength.",
    "No patient-specific diagnosis, treatment recommendation, dosing, triage, alarm, or autonomous decision.",
    "No claim of clinical, regulatory, legal, or HIPAA compliance."
  ],
  "limitations": [
    "No certainty judgment is inferred from text or study design.",
    "Certainty is outcome-specific.",
    "Recommendation development requires a separate human Evidence-to-Decision process."
  ],
  "human_review": {
    "required": true,
    "roles": [
      "systematic-review methodologist",
      "domain expert",
      "GRADE panel chair"
    ],
    "completed": false
  },
  "governance": {
    "version": "0.1-draft",
    "owner": "REPLACE_WITH_EVIDENCE_PROFILE_OWNER_ROLE",
    "change_summary": "Initial unresolved template.",
    "auditability": "Retain searches, selection decisions, source versions, domain judgments, disagreements, and approvals.",
    "update_plan": "Define surveillance, update triggers, supersession, and retirement."
  },
  "question": {
    "population": "REPLACE_WITH_DEFINED_POPULATION",
    "intervention_or_exposure": "REPLACE_WITH_INTERVENTION_OR_EXPOSURE",
    "comparator": "REPLACE_WITH_COMPARATOR",
    "setting": "REPLACE_WITH_SETTING",
    "outcomes": [
      "REPLACE_WITH_IMPORTANT_OUTCOME_AND_TIME_HORIZON"
    ]
  },
  "sources": [
    {
      "id": "SRC-001",
      "citation": "REPLACE_WITH_FULL_CITATION",
      "url": "REPLACE_WITH_CANONICAL_URL",
      "accessed": "YYYY-MM-DD"
    }
  ],
  "outcomes": [
    {
      "name": "REPLACE_WITH_OUTCOME",
      "importance": "critical",
      "effect_measure": "REPLACE_WITH_EFFECT_MEASURE",
      "effect_estimate": "REPLACE_WITH_ABSOLUTE_AND_RELATIVE_EFFECTS",
      "uncertainty_interval": "REPLACE_WITH_INTERVAL",
      "participants": "REPLACE_WITH_NUMBER_AND_ANALYSIS_POPULATION",
      "studies": "REPLACE_WITH_NUMBER_AND_DESIGNS",
      "time_horizon": "REPLACE_WITH_TIME_HORIZON",
      "domains": {
        "risk_of_bias": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "reviewer_role": "REPLACE_WITH_REVIEWER_ROLE",
          "source_ids": [
            "SRC-001"
          ]
        },
        "inconsistency": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "reviewer_role": "REPLACE_WITH_REVIEWER_ROLE",
          "source_ids": [
            "SRC-001"
          ]
        },
        "indirectness": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "reviewer_role": "REPLACE_WITH_REVIEWER_ROLE",
          "source_ids": [
            "SRC-001"
          ]
        },
        "imprecision": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "reviewer_role": "REPLACE_WITH_REVIEWER_ROLE",
          "source_ids": [
            "SRC-001"
          ]
        },
        "publication_bias": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "reviewer_role": "REPLACE_WITH_REVIEWER_ROLE",
          "source_ids": [
            "SRC-001"
          ]
        }
      },
      "upgrading": {
        "large_effect": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "source_ids": []
        },
        "dose_response": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "source_ids": []
        },
        "residual_confounding": {
          "judgment": "unassessed",
          "rationale": "REQUIRES_HUMAN_JUDGMENT",
          "source_ids": []
        }
      },
      "certainty": {
        "human_judgment": false,
        "level": "unassessed",
        "rationale": "REQUIRES_HUMAN_PANEL_JUDGMENT",
        "reviewer_role": "REPLACE_WITH_PANEL_ROLE",
        "judgment_date": "YYYY-MM-DD",
        "source_ids": [
          "SRC-001"
        ]
      }
    }
  ],
  "profile_review": {
    "prepared_by_role": "REPLACE_WITH_ROLE",
    "reviewed_by_role": "REPLACE_WITH_ROLE",
    "review_date": "YYYY-MM-DD",
    "completed": false
  }
}